Missouri Technology Expo 2010 (MU)
https://hdl.handle.net/10355/9597
The Expo fosters relationships between the MU academic community and industry partners and thus serve as catalyst for economic development.2024-03-28T21:35:23ZAccrualMaster : software for planning and monitoring accrual rates in clinical trials [abstract]
https://hdl.handle.net/10355/9691
AccrualMaster : software for planning and monitoring accrual rates in clinical trials [abstract]
Simon, Stephen; Gajewski, Byron
The most common reason why clinical trials fail is that they fall well below their goals for patient accrual. Researchers will frequently overpromise and underdeliver on the number of patients that they can recruit during the proposed time frame. The result is studies that take far longer than planned and/or that end with fewer patients than planned. This raises serious economic and ethical issues. We have developed a Bayesian model for accrual that will encourage careful planning of accrual rates as well as allow regular monitoring of accrual patterns during the conduct of the clinical trial. We have developed software in R that can show graphically the expected duration of the trial under initial planning estimates of accrual rates and that can adjust those accrual rates as the trial progresses by combing the actual accrual data with the prior beliefs of accrual. This software can be used by individual researchers, by Institution Review Boards during their continuing review of approved projects, and by Data Safety and Monitoring Boards during their interim analysis. We are working on extensions of the software to multi-center trials, to assessing the impact of refusal rates and losses due to exclusion criteria, and to non-uniform accrual rates (e.g., accrual rates in a trial expected to have a slow startup period). We are looking for support and collaborators to make the software available on a R server computer using a simplified front-end interface, to test the software prospectively in a series of clinical trials, and to support research on the extensions to new and important areas.
2010-10-01T00:00:00ZAccurate and affordable allergen quantification for the seed biotech industry
https://hdl.handle.net/10355/9624
Accurate and affordable allergen quantification for the seed biotech industry
Thelen, Jay J.; Stevenson, Severin E.
Plant seeds provide a significant portion of the protein present in the human diet, but are also the major contributors of allergenic proteins that cause a majority of the reported cases of food-induced anaphylaxis in the U.S. It is estimated that as many as 12 million Americans have food allergies, and there is a need for better methods for analytical screening of foods, or protein phenotyping, particularly for the seed industry. The current invention developed by researchers at the University of Missouri is a high-throughput, inexpensive workflow for quantifying prominent plant seed proteins. This was done by developing a mass spectrometry-based workflow beginning with intact, whole plant seed. The method does not require gel electrophoresis, antibodies, chemical labeling or a priori information about the seed to be analyzed.
This presentation was made as part of the Life Science Elevator Pitch session.
2010-10-01T00:00:00ZAdsorbed natural gas (ANG) technology
https://hdl.handle.net/10355/9765
Adsorbed natural gas (ANG) technology
Pfeifer, Peter; Suppes, Galen J.; Shah, Parag S.; Burress, Jacob W., 1983-; Pobst, Jeff
This invention teaches a method of manufacturing carbon so that it adsorbs large amounts of gas at low pressures due to the high surface area and associated nanopores. For example, a full tank of this carbon can hold more than three times (3x) the amount of natural gas at 500 psig than an otherwise empty tank at the same pressure. The high surface area adsorbs gas molecules by the nature of surface attraction forces. This invention has multiple viable applications. The largest market is in motor vehicles, and this research team at the University of Missouri was the first and only to reach the Department of Energy's target of holding 150x storage capacity at 500 psig (this team actually achieved 180x). This invention also covers high pressure storage, where adsorption is slightly better than ordinary compression. Because other gases adsorb onto activated carbon, this invention likely has many other applications in gaseous storage and it is made from an abundant and inexpensive source, corn cobs. Potential Areas of Applications: * Natural gas or hydrogen powered vehicles * Upstream oil operations or natural gas collection and shipping * Miscellaneous smaller markets such as oxygen tanks and other gas tanks Patent Status: Non provisional patent application on file Inventor(s): Peter Pfeifer, Galen Suppes, Parag Shah, Jacob Burress, Jeffrey Pobst Contact Info: Dr. Wayne McDaniel, Ph.D. ; McDanielWC@missouri.edu ; 573-884-3302
2010-10-01T00:00:00ZAdvanced spectroscopic technologies
https://hdl.handle.net/10355/9797
Advanced spectroscopic technologies
Advanced Spectroscopic Technologies
Advanced Spectroscopic Technologies of St. Louis, Missouri presented a corporate overview, technology and developments within the company and opportunities for investors.
2010-10-01T00:00:00Z