Browsing University of Missouri-Columbia by Thesis Advisor "Alexander, Stephen, 1948-"
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Drug resistance in D. discoideum: isolation of 4-nitroquinoline 1-oxide resistant mutants
(University of Missouri--Columbia, 2005)The drug 4-nitroquinoline 1-oxide (4NQO) displays both carcinogenic and antitumor effects, a well known characteristic of many chemotherapeutic drugs. In addition 4NQO shares a similar operating mechanism with the commonly ... -
Regulation of ceramide synthase 1 in cellular stress response
(University of Missouri--Columbia, 2008)Ceramides are intimately involved in a wide range of cellular processes. In mammals, de novo ceramide synthesis is catalyzed by the 6 ceramide synthase enzymes, which are homologs of the yeast longevity assurance gene ... -
Sphingolipid metabolic enzymes modulate anticancer drug resistance
(University of Missouri--Columbia, 2006)Resistance to anticancer drugs is still a big obstacle for effective chemotherapy.To understand the underlying mechanisms, we generated sphingosine-1-phosphate (S-1-P)lyase (SPL) and sphingosine kinase (SK) mutants. Our ...