Browsing University of Missouri-Columbia by Thesis Advisor "Burke, Donald H."
Now showing items 1-6 of 6
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Advances in aptamer evolution and engineering
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Aptamers are single-stranded nucleic acids that fold into unique three-dimensional shapes that allow them to bind with high affinity and specificity ... -
Aptamers that bind filovirus GP : a new frontier for detection and neutralization of Ebola and Marburg virus
(University of Missouri--Columbia, 2020)Aptamers are single chained, nucleic acid-based affinity probes that bind to their targets with strong affinity and specificity. They are made through an in vitro combinatorial selection method, wherein large libraries of ... -
Characterization of HIV-1 reverse transcriptase drug resistance connection subdomain mutation N348I
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Connection subdomain mutations are a recently discovered class of reverse transcriptase (RT) drug resistance mutations which are positioned at some ... -
The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2010)Human Immunodeficiency Virus (HIV) reverse transcriptase (RT) is the most common molecular target of current HIV treatments. Oligonucleotide aptamers bind and inhibit the RNA- and DNA-dependent polymerization activities ... -
Sequence and secondary structural analysis of a novel class of RNA aptamers that inhibit reverse transcriptase
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] RNA aptamers are synthetic RNAs selected for their ability to bind a molecular target. Reverse Transcriptase (RT) is the major target of antiretroviral ... -
Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As we narrowly focus on the fundamental questions of our respective systems it is important to interact with the broader scientific community to gain ...