• Can we prevent splenic rupture for patients with infectious mononucleosis? 

    Foreman, Brett H.; Mackler, Leslie (Family Physicians Inquiries Network, 2005-06)
    All patients with infectious mononucleosis should be considered at risk for splenic rupture since clinical severity, laboratory results, and physical exam are not reliable predictors of rupture (strength of recommendation ...
  • Do glucosamine or chondroitin cause regeneration of cartilage in osteoarthritis? 

    Priebe, David; McDiarmid, Todd; Mackler, Leslie (Family Physicians Inquiries Network, 2003-03)
    No direct evidence suggests glucosamine or chrondroitin cause regeneration of cartilage in osteoarthritis. Use of glucosamine sulfate in knee osteoarthritis prevents joint space narrowing on radiographs (strength of ...
  • Do systemic corticosteroids lessen symptoms in acute exacerbations of COPD? 

    McDiarmid, Todd; Mackler, Leslie (Family Physicians Inquiries Network, 2003-12)
    Systemic corticosteroids improve measures of dyspnea in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) (strength of recommendation [SOR]: A, meta-analysis of 2 small randomized controlled ...
  • Does quinine reduce leg cramps for young athletes? 

    Robertson, Noelle; Hale, Wayne A.; Mackler, Leslie (Family Physicians Inquiries Network, 2005-01)
    Very little evidence exists regarding the use of quinine for cramps in young adult athletes. Quinine may be an effective treatment for heat cramps in athletes (strength of recommendation [SOR]: C, 1 case series involving ...
  • Does warfarin prevent deep venous thrombosis in high-risk patients? 

    Spaulding, Rebecca L.; Chambliss, M. Lee; Mackler, Leslie (Family Physicians Inquiries Network, 2004-03)
    Warfarin (Coumadin) is effective in preventing deep venous thrombosis (DVT) among patients with a history of DVT. Conventional dosing and longer durations are the most effective, but the ideal length of therapy is unknown ...
  • How should a DEXA scan be used to evaluate bisphosphonate therapy for osteoporosis? 

    Koval, Peter G.; Easterling, Lisa; Pettus, Dawn; Mackler, Leslie (Family Physicians Inquiries Network, 2005-01)
    If bone density is evaluated after initiating bisphosphonate drug therapy, it should be tested no earlier than 2 years (strength of recommendation [SOR]: B, based on case series of dual energy x-ray absorptiometry [DEXA] ...
  • Is an outpatient workup safe for patients with a transient ischemic attack? 

    Franklin, Melissa; McDiarmid, Todd; Mackler, Leslie (Family Physicians Inquiries Network, 2004-07)
    There is no compelling evidence that outpatient diagnostic workup of patients with transient ischemic attack (TIA) is less safe than inpatient workup, or that hospitalization prevents stroke or improves stroke outcomes ...
  • Is folate supplementation indicated for patients with CAD? 

    Hecox, Kerri; Hale, Wayne A.; Mackler, Leslie (Family Physicians Inquiries Network, 2004-01)
    There is insufficient evidence to advocate the routine use of folate supplementation for the treatment of coronary artery disease (CAD). High levels of serum homocysteine have been associated in several studies with an ...
  • What is the addiction risk associated with tramadol? 

    McDiarmid, Todd; Mackler, Leslie (Family Physicians Inquiries Network, 2005-01)
    Tramadol (Ultram, generic and with acetaminophen in Ultracet) carries a risk of substance abuse (strength of recommendation [SOR]: B, based on case report surveillance programs). While it appears that tramadol's risk of ...
  • What is the best treatment for Osgood-Schlatter disease? 

    Bloom, O. Josh; Mackler, Leslie (Family Physicians Inquiries Network, 2004-02)
    Osgood-Schlatter disease is a common cause of pain and tenderness at the tibial tuberosity in active adolescents. It is typically a self-limited condition that waxes and wanes, but which often takes months to years to ...
  • What is the diagnostic approach to a patient with leg cramps? 

    Shaker, Hayam K.; Mackler, Leslie (Family Physicians Inquiries Network, 2005-09)
    Leg cramps are very common (strength of recommendation [SOR]: C, case series), and most cases have no detectable cause (SOR: C, expert opinion). Arterial vascular disease and neurological diseases are more prevalent among ...
  • What physical exam techniques are useful to detect malingering? 

    Greer, Steven; Chambliss, M. Lee; Mackler, Leslie (Family Physicians Inquiries Network, 2005-08)
    No examination technique objectively proves malingering (strength of recommendation [SOR]: C, expert opinion). Waddell's signs are associated with poor treatment outcomes but cannot discriminate organic from nonorganic ...