• Contribution of the immune system and astrocytes to spinal muscular atrophy pathology 

    Khairallah, Marie-Therese (University of Missouri--Columbia, 2018)
    Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and the leading genetic cause of infant mortality. SMA is caused by afunctional loss of the survival motor neuron-1 (SMN1) gene and the subsequent ...
  • Duchenne muscular dystrophy gene therapy in the canine model 

    Kodippili, Kasun (University of Missouri--Columbia, 2018)
    Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by loss of function mutations in the dystrophin gene, resulting in the absence of dystrophin, a structural protein in muscle. DMD is the most ...
  • Mechanisms of clostridial toxin binding and translocation 

    Lambert, Gregory Stephen (University of Missouri--Columbia, 2018)
    The bacterial genus Clostridium consists of over 150 species of anaerobic, fermentative, spore-forming bacilli. Clostridial species produce up to 20% of all known bacterial exotoxins, which serve as important virulence ...
  • Mechanisms of immunity and inflammation in Brucella-induced arthritis 

    Lacey, Carolyn Ann (University of Missouri--Columbia, 2018)
    "Treatment of unresolved sterile arthritis such as rheumatoid arthritis or osteoarthritis involves eliminating or dampening host inflammatory responses. While inflammation may inflict severe articular pathology to the host ...
  • Protection from pneumonic plague by the induction of heme oxygenase-1 

    Willix, Joshua (University of Missouri--Columbia, 2018)
    Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ...