Browsing University of Missouri-Columbia by Thesis Advisor "Pintel, David J."
Now showing items 1-7 of 7
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Characterization of the non-structural proteins of adeno-associated virus (AAV) and minute virus of canine (MVC)
(University of Missouri--Columbia, 2012)Parvoviruses are among the smallest of the animal DNA viruses. Due to their compact genome, these viruses display immense heterogeneity both in the mechanisms involved in gene expression and the functions of the encoded ... -
Characterization of the role of adenovirus-5 (Ad-5) gene products E2A, E4ORF6 and VA RNA on adeno-associated virus type 5 (AAV5) transcription, translation and replication
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] AAV5 is the most distinct serotype of the AAVs differing from the prototype virus AAV2 at the nucleotide level. We show that in AAV5 the Rep transcripts ... -
Characterization of the role of the DNA damage response pathway in parvoviral replication
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] We report that low multiplicity infection with the autonomous parvovirus minute virus of mice (MVM) results in the activation of a DNA damage response ... -
Determinants that govern alternative splicing of the large intron of minute virus of mice p4-generated PRE-mRNA
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Following transfection of murine fibroblasts, MVMi does not efficiently produce progeny single-strand DNA (ssDNA). However, changing a single nucleotide ... -
The Parvovirus Minute Virus of Mice modulates the DNA damage response to facilitate viral replication and a pre-mitotic cell cycle block /
(University of Missouri--Columbia, 2017)The DNA damage response (DDR) is a critical cellular network that affords cells the ability to repair DNA damage they have incurred from endogenous and exogenous sources. Recently, it has become appreciated that viruses, ... -
Protein processing strategies by adeno-associated virus type 5 (AAV5) and the effects of the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex on AAV protein stability
(University of Missouri--Columbia, 2008)We report the initial identification of the ubiquitination of a parvovirus non-structural protein by the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex. The small Rep and capsid proteins of adeno-associated ... -
Transcription regulation of adeno-associated viruses
(University of Missouri--Columbia, 2007)The small genome size of adeno-associated viruses demand efficient gene regulation achieved by various strategies. This research compared these strategies from AAV2, AAV5 and bovine-AAV, and found that AAV2 capsid promoter ...