Browsing University of Missouri-Columbia by Thesis Advisor "Sowers, James R. (James Russell), 1942-"
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Beta cell dysfunction, oxidative stress and S6K1 activation in pancreas in the Zucker obese rat model [abstract]
(2010)Insulin resistance and beta cell dysfunction are leading components in the pathogenesis of type 2 diabetes mellitus. Over-nutrition leads to activation of the mTOR/S6K1. S6K1 activation leads to serine phosphorylation of ... -
Retinal redox stress and ultrastructural remodeling in metabolic syndrome and diabetic retinopathy [abstract]
(2010)Diabetic retinopathy is the major cause of blindness in the United States in the age group from 20-74. There are four traditional metabolic pathways involved in the development of diabetic retinopathy: increased polyol ...