• Detection of CD4 and CD8 t-lymphocytes and HER2 breast cancer biomarker using the opto-fluidic ring resonator biosensor 

    Gohring, John Thomas, 1984- (University of Missouri--Columbia, 2009)
    We have demonstrated label-free detection of CD4+ and CD8+ T-Lymphocytes and HER2 breast cancer biomarker using the opto-fluidic ring resonator (OFRR) sensor. The OFRR sensing platform incorporates microfluidics and photonics ...
  • Immunotherapy for autoimmune diabetes 

    Jain, Renu, 1979- (University of Missouri--Columbia, 2008)
    Type I diabetes (TID) is an autoimmune disorder wherein the insulin producing beta (Beta) cells of the pancreatic islets of Langerhans are destroyed specifically by the [Beta]-cell antigen specific T cells. Numerous ...
  • Regulating the regulators: using CD25 depletion to enhance immune responses to a model plasmid-based vaccine 

    Thoma, Michelle C. (University of Missouri--Columbia, 2008)
    Due to their ease of production and safety, plasmid-based vaccines have become prime candidates for both prophylactic and therapeutic human vaccination. In experimental animal models, vaccination with plasmid DNA expression ...
  • Role of T Cell Receptor Signaling in CD8 T Cell Memory 

    Knudson, Karin M. (University of Missouri--Columbia, 2015)
    The generation of immunological memory is the basis for vaccination. The development of memory CD8 T cells is required for long-term protection against intracellular pathogens, such as viruses, and tumors. While the ...
  • SIRT1 deacetylation regulates NFAT transcriptional activity 

    Shannon, Stephen G., 1975- (University of Missouri--Columbia, 2009)
    The class III histone deacetylase SIRT1 plays important roles in aging, metabolism and biological clock control. We have recently demonstrated that SIRT1 is a critical factor to control immune functions. However, the ...
  • Thymus 

    Krause, William J., II, 1942- (William J. Krause, 2008-09)
    Histology blog entry for September 19, 2008 about the thymus.
  • Two aspects of peripheral immune tolerance: systemic and mucosal tolerance mechanisms 

    Divekar, Rohit Dilip, 1978- (University of Missouri--Columbia, 2008)
    Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune disease have not been entirely characterized. Autoimmunity develops ...