Browsing University of Missouri-Columbia by Thesis Department "Veterinary pathobiology area program (MU)"
Now showing items 1-20 of 47
-
Adding pieces to the monocytic ehrlichiosis puzzle : treatment, etiology and protection with a canine model
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Infections with Ehrlichia canis cause Canine Monocytic Ehrlichiosis (CME), a disease which causes morbidity and mortality of dogs worldwide. Currently, ... -
Advances in the fundamental cryobiology of mammalian oocytes
(University of Missouri--Columbia, 2007)Having effective means to cryopreserve mammalian oocytes could increase the efficiency of managing populations of laboratory animals, increase the effectiveness of breeding programs for livestock, and improve the means by ... -
Amino-terminal sequences of the bacillus anthracis exosporium proteins BCLA and BCLB important for localization and attachment to the spore surface
(University of Missouri--Columbia, 2008)The exosporium is the outermost layer of the Bacillus anthracis spore. The predominant protein on the exosporium surface is BclA, a collagen-like glycoprotein. BclA is incorporated on the spore surface late in the B. ... -
Autologous bone marrow-derived mesenchymal stem cell transplantation as a therapy for neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2007)The Neuronal Ceroid Lipofuscinoses (NCLs) are a group of rare genetic diseases characterized by neurodegeneration and accumulation of autofluorescent lysosomal storage bodies in numerous cell types. There are currently no ... -
Biodistribution of lead, arsenic, and gold nanoparticles following respiratory, oral and IV exposure of rats and swine
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The presence of arsenic and lead in the environment above the naturally occurring levels can have detrimental health effects on people living in these ... -
Characterization of interactions involving the polycystic kidney disease-causing proteins: SamCystin and Bicc1
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rodent models, including the Han:SPRD-Cy rat and the jcpk mouse, have been useful for identifying and characterizing genes that cause Polycystic Kidney ... -
Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteogenesis imperfecta (OI) is a heritable connective tissue disorder hallmarked by bone fragility resulting primarily from mutations in the ... -
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ... -
Characterization of the sporozoite and eythrocytic stages (SES) protein
(University of Missouri--Columbia, 2007)The Plasmodium sporozoite is infective for mosquito salivary glands and vertebrate host tissues. Although it is a key developmental stage of the malaria parasite, relatively few sporozoite surface or secreted proteins have ... -
Characterizing the progression of disease associated with human meniscal pathology
(University of Missouri--Columbia, 2013)Meniscal fibrocartilaginous structures are subject to numerous stresses when performing its necessary functions to maintain intra-articular homeostasis. Pathological events causing a loss of tissue integrity will result ... -
Comparative fundamental cryobiology of mouse embryonic stem cells
(University of Missouri--Columbia, 2009)Mouse embryonic stem cell (mESC) lines are central to projects such as the Knock-Out Mouse Project, which seek to create thousands of mutant mouse strains using mESCs for the production of human disease models. The ability ... -
Cruciate ligament pathogenesis and its role in the initiation and progression of osteoarthritis
(University of Missouri--Columbia, 2008)The pathogenesis of cruciate ligament disease and how it may be linked to the initiation and progression of osteoarthritis were investigated using in vitro and in vivo models. Normal and diseased tissues were initially ... -
Decreasing perinatal bovine leukosis virus infection in calves
(University of Missouri--Columbia, 2006)Bovine leukosis virus (BLV) is an oncogenic retrovirus of cattle that causes lymphosarcoma in a proportion of infected individuals. Currently the United States estimates are that 44% of dairy cattle and 10% of beef cattle ... -
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ... -
Diagnosis, epidemiology and immunologic consequences of copper deficiency in calves
(University of Missouri--Columbia, 2006)Copper is an essential micronutrient. Copper deficiency has been associated with disease states that decrease commercial beef production. Clinical manifestations of copper disease include anemia, diarrhea, long bone ... -
DLC1 as a comparative epigenetic biomarker for radiotherapy of Non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2007)The American Cancer Society estimates that 58,870 people were diagnosed with non-Hodgkin's lymphoma (NHL) in 2006, and 18,840 people died of the disease. Recent investigation of epigenetic gene regulation has identified ... -
Ecomorphological implications of primate dietary variability: an experimental model
(University of Missouri--Columbia, 2013)The evolution and function of the mammalian skull and feeding apparatus is intimately related to the mechanical demands imposed by food items. The diets of wild species are often seasonal and thus individuals may experience ... -
Effect of colostral administration practices on serum immunoglobulin concentration in dairy calves
(University of Missouri--Columbia, 2008)Despite the accumulated understanding of the factors which affect passive transfer of colostral immunoglobulins and its recognized importance in dairy calves, approximately 35-40 % of US dairy calves have inadequate passive ... -
The evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilage
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage ... -
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...