What is the most effective treatment for community-acquired pneumonia in immunocompromised adults?
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Initial empiric dual-therapy with a β-lactam antibiotic and a macrolide decreases mortality in immunocompromised patients (IPs) with community-acquired pneumonia with bacteremia compared with monotherapy. (SOR: C, a secondary outcome in a retrospective cohort study.) If resistance due to beta-lactamase is a concern, a broader-spectrum antibiotic (eg, cefepime or imipenem) may be appropriate for IPs with known pneumococcemia. (SOR: C, extrapolated from a retrospective cohort study.)
Evidence Based Practice 14(2): 12.