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dc.contributor.authorDorgan, Joanne F.eng
dc.contributor.authorLongcope, Christophereng
dc.contributor.authorStephenson, Hugh E.eng
dc.contributor.authorFalk, Roni T.eng
dc.contributor.authorMiller, Rosettaeng
dc.contributor.authorFranz, Charleneeng
dc.contributor.authorKahle, Lisaeng
dc.contributor.authorCampbell, William S.eng
dc.contributor.authorTangrea, Joseph A.eng
dc.contributor.authorSchatzkin, Arthureng
dc.date.issued1997-04eng
dc.descriptionReproduced with permission from Environmental Health Perspectives.eng
dc.description.abstractWe conducted a nested case-control study to prospectively evaluate the relationship of serum estrogens and androgens to risk of breast cancer in postmenopausal women. From 1977 to 1987, 3375 postmenopausal women free of cancer and not taking replacement estrogens donated blood to the Breast Cancer Serum Bank in Columbia, Missouri. Of these, 72 were subsequently diagnosed with breast cancer. For each case, two controls matched on age and date and time of day of blood collection were selected using incidence density matching. The median age of subjects at blood collection was 62 years; the time from blood collection to diagnosis ranged from less than 1 to 9.5 years with a median of 2.9 years. Risk of breast cancer was positively and significantly associated with serum levels of estrogens and androgens. Compared to women in the lowest quartile, those in the highest quartile for non-sex hormone-binding globulin (non-SHBG) bound (bioavailable) estradiol had a relative risk of 5.2 (95% confidence interval [CI] = 1.5-18.5) and those in the highest quartile for testosterone had a relative risk of 6.2 (95% CI = 2.0-19.0). Our results lend considerable support to the hypothesis that serum concentrations of estrogens and androgens are related to the subsequent diagnosis of breast cancer in postmenopausal women.eng
dc.identifier.citationDorgan JF, Longcope C, Stephenson HE Jr, Falk RT, Miller R, Franz C, et al. Serum sex hormone levels are related to breast cancer risk in postmenopausal women. Environmental Health Perspectives 1997;105 Suppl 3:583-5.eng
dc.identifier.urihttp://hdl.handle.net/10355/10104eng
dc.publisherNational Institute of Environmental Health Scienceseng
dc.relation.ispartofSurgery publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. School of Medicine. Department of Surgeryeng
dc.source.harvestedPubMed Centraleng
dc.subjectbreast cancer riskeng
dc.subject.lcshEstradioleng
dc.subject.lcshAndrogenseng
dc.subject.lcshBreast -- Cancereng
dc.subject.lcshOlder women -- Diseaseseng
dc.titleSerum Sex Hormone Levels Are Related to Breast Cancer Risk in Postmenopausal Womeneng
dc.typeArticleeng


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