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dc.contributor.authorKaragas, Margaret R.eng
dc.contributor.authorTosteson, Tor D.eng
dc.contributor.authorBlum, Joeleng
dc.contributor.authorMorris, Steveeng
dc.contributor.authorBaron, Johneng
dc.contributor.authorKlaue, Bjoerneng
dc.coverage.spatialNew Hampshireeng
dc.date.issued1999eng
dc.descriptionReproduced with permission from Environmental Health Perspectives.eng
dc.description.abstractIngestion of arsenic-contaminated drinking water is associated with an increased risk of several cancers, including skin and bladder malignancies; but it is not yet clear whether such adverse effects are present at levels to which the U.S. population is exposed. In New Hampshire, detectable levels of arsenic have been reported in drinking water supplies throughout the state. Therefore, we have begun a population-based epidemiologic case-control study in which residents of New Hampshire diagnosed with primary squamous cell (n=900) and basal cell (n=1200) skin cancers are being selected from a special statewide skin cancer incidence survey ; patients diagnosed with primary bladder cancers (n=450) are being identified through the New Hampshire State Cancer Registry. Exposure histories of these patients will be compared to a control group of individuals randomly selected from population lists (n=1200) . Along with a detailed personal interview, arsenic and other trace elements are being measured in toenail clipping samples using instrumental neutron activation analysis. Household water samples are being tested on selected participants using a hydride generation technique with high-resolution inductively coupled plasma mass spectrometry. In the first 793 households tested, arsenic concentrations ranged from undetectable (0.01 [mu]g/l) to 180 [mu]g/l. Over 10% of the private wells contained levels above 10 [mu]g/l and 2.5% were above 50 [mu]g/l. Based on our projected sample size, we expect at least 80% power to detect a 2-fold risk of basal cell or squamous cell skin cancer or bladder cancer among individuals with the highest 5% toenail concentrations of arsenic.eng
dc.description.sponsorshipFunding for the study was provided by the National Institutes of Health grants NIEHS ES-07373.eng
dc.identifier.citationKaragas MR, Tosteson TD, Blum J, et al. Design of an epidemiologic study of drinking water arsenic exposure and skin and bladder cancer risk in a US population. Environmental Health Perspectives 1998;106 (suppl 4):1047-50.eng
dc.identifier.urihttp://hdl.handle.net/10355/10114eng
dc.languageEnglisheng
dc.publisherNational Institute of Environmental Health Scienceseng
dc.relation.ispartofMissouri Research Reactor publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. University of Missouri Research Reactor Centereng
dc.sourceHarvested from: PubMed Central - Canadaeng
dc.subject.lcshCancer -- Risk factorseng
dc.subject.lcshDrinking water -- Arsenic contenteng
dc.titleDesign of an Epidemiologic Study of Drinking Water Arsenic Exposure and Skin and Bladder Cancer Risk in a U.S. Populationeng
dc.typeArticleeng


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