Developmental Effects of Endocrine-Disrupting Chemicals in Wildlife and Humans

MOspace/Manakin Repository

Breadcrumbs Navigation

Developmental Effects of Endocrine-Disrupting Chemicals in Wildlife and Humans

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/10115

[+] show full item record


Title: Developmental Effects of Endocrine-Disrupting Chemicals in Wildlife and Humans
Author: Colborn, Theo; vom Saal, Frederick S.; Soto, A. M. (Ana M.)
Date: 1993-10
Publisher: National Institute of Environmental Health Sciences
Citation: Colborn T, Vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environmental Health Perspectives 1993;101(5):378-384
Abstract: Large numbers and large quantities of endocrine-disrupting chemicals have been released into the environment since World War II. Many of these chemicals can disturb development of the endocrine system and of the organs that respond to endocrine signals in organisms indirectly exposed during prenatal and/or early postnatal life; effects of exposure during development are permanent and irreversible. The risk to the developing organism can also stem from direct exposure of the offspring after birth or hatching. In addition, transgenerational exposure can result from the exposure of the mother to a chemical at any time throughout her life before producing offspring due to persistence of endocrine-disrupting chemicals in body fat, which is mobilized during egg laying or pregnancy and lactation. Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
URI: http://hdl.handle.net/10355/10115

This item appears in the following Collection(s)

[+] show full item record