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dc.contributor.advisorLever, Susan Z., 1952-eng
dc.contributor.authorChen, Peter, 1984-eng
dc.date.issued2009eng
dc.date.submitted2009 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on February 22, 2011).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. Susan Z. Lever.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.S. University of Missouri--Columbia 2009.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Chemistry.eng
dc.description.abstractThe sigma receptor has been biologically found to play roles in the central nervous system (CNS) disorders and cancer cell proliferation. With the identification of lead sigma receptor binding ligands by previous structure activity relationship (SAR) studies, new sigma Tc-⁹⁹[superscript m] sigma receptor imaging agents were designed. Tc-⁹⁹ [superscript m] imaging agents provide the advantages for routing clinical use due to its ideal nuclear properties (t₁/₂=6 hours and 140 keV gamma photon emission) and being readily available from a ⁹⁹Mo/⁹⁹[superscript m] Tc generator. The stability, structure, and biodistribution of rhenium complexes have been found similar to their Tc-⁹⁹ [superscript m] counterparts. Non-radioactive rhenium surrogates serve as a useful precursor for the radioactive Tc-⁹⁹ [superscript m] imaging agents. The Re/Tc-⁹⁹ [superscript m] are bound by the amide-amine-dithiol tetradentate (AADT) chelate and linked onto the sigma moieties following the bifunctional chelate approach. The current study, successfully synthesized the chelate, sigma moieties, and target rhenium surrogates toward the goal of developing new sigma receptor imaging agents.eng
dc.format.extentix, 109 pageseng
dc.identifier.oclc703666966eng
dc.identifier.otherChenP-120909-T2795eng
dc.identifier.urihttp://hdl.handle.net/10355/10131eng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2009 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2009 Theseseng
dc.subject.lcshSigma receptorseng
dc.subject.lcshRhenium compoundseng
dc.subject.lcshImaging systems in chemistryeng
dc.subject.lcshCancer cells -- Proliferationeng
dc.subject.lcshCentral nervous system -- Cancereng
dc.titleSynthesis of rhenium complexes as models for new sigma receptor imaging agentseng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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