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dc.contributor.advisorLever, Susan Z., 1952-en_US
dc.contributor.authorChen, Peter, 1984-en_US
dc.date.issued2009eng
dc.date.submitted2009 Fallen_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on February 22, 2011).en_US
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.en_US
dc.descriptionThesis advisor: Dr. Susan Z. Lever.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionM.S. University of Missouri--Columbia 2009.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Chemistry.en_US
dc.description.abstractThe sigma receptor has been biologically found to play roles in the central nervous system (CNS) disorders and cancer cell proliferation. With the identification of lead sigma receptor binding ligands by previous structure activity relationship (SAR) studies, new sigma Tc-⁹⁹[superscript m] sigma receptor imaging agents were designed. Tc-⁹⁹ [superscript m] imaging agents provide the advantages for routing clinical use due to its ideal nuclear properties (t₁/₂=6 hours and 140 keV gamma photon emission) and being readily available from a ⁹⁹Mo/⁹⁹[superscript m] Tc generator. The stability, structure, and biodistribution of rhenium complexes have been found similar to their Tc-⁹⁹ [superscript m] counterparts. Non-radioactive rhenium surrogates serve as a useful precursor for the radioactive Tc-⁹⁹ [superscript m] imaging agents. The Re/Tc-⁹⁹ [superscript m] are bound by the amide-amine-dithiol tetradentate (AADT) chelate and linked onto the sigma moieties following the bifunctional chelate approach. The current study, successfully synthesized the chelate, sigma moieties, and target rhenium surrogates toward the goal of developing new sigma receptor imaging agents.en_US
dc.format.extentix, 109 pagesen_US
dc.identifier.oclc703666966en_US
dc.identifier.otherChenP-120909-T2795en_US
dc.identifier.urihttp://hdl.handle.net/10355/10131
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2009 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2009 Theses
dc.subject.lcshSigma receptorsen_US
dc.subject.lcshRhenium compoundsen_US
dc.subject.lcshImaging systems in chemistryen_US
dc.subject.lcshCancer cells -- Proliferationen_US
dc.subject.lcshCentral nervous system -- Canceren_US
dc.titleSynthesis of rhenium complexes as models for new sigma receptor imaging agentsen_US
dc.typeThesisen_US
thesis.degree.disciplineChemistryeng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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