Synthesis of rhenium complexes as models for new sigma receptor imaging agents

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Synthesis of rhenium complexes as models for new sigma receptor imaging agents

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/10131

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dc.contributor.advisor Lever, Susan Z., 1952- en_US
dc.contributor.author Chen, Peter, 1984- en_US
dc.date.accessioned 2011-03-04T15:11:54Z
dc.date.available 2011-03-04T15:11:54Z
dc.date.issued 2009 en_US
dc.date.submitted 2009 Fall en_US
dc.identifier.other ChenP-120909-T2795 en_US
dc.identifier.uri http://hdl.handle.net/10355/10131
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on February 22, 2011). en_US
dc.description The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. en_US
dc.description Thesis advisor: Dr. Susan Z. Lever. en_US
dc.description Includes bibliographical references. en_US
dc.description M.S. University of Missouri--Columbia 2009. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Chemistry. en_US
dc.description.abstract The sigma receptor has been biologically found to play roles in the central nervous system (CNS) disorders and cancer cell proliferation. With the identification of lead sigma receptor binding ligands by previous structure activity relationship (SAR) studies, new sigma Tc-⁹⁹[superscript m] sigma receptor imaging agents were designed. Tc-⁹⁹ [superscript m] imaging agents provide the advantages for routing clinical use due to its ideal nuclear properties (t₁/₂=6 hours and 140 keV gamma photon emission) and being readily available from a ⁹⁹Mo/⁹⁹[superscript m] Tc generator. The stability, structure, and biodistribution of rhenium complexes have been found similar to their Tc-⁹⁹ [superscript m] counterparts. Non-radioactive rhenium surrogates serve as a useful precursor for the radioactive Tc-⁹⁹ [superscript m] imaging agents. The Re/Tc-⁹⁹ [superscript m] are bound by the amide-amine-dithiol tetradentate (AADT) chelate and linked onto the sigma moieties following the bifunctional chelate approach. The current study, successfully synthesized the chelate, sigma moieties, and target rhenium surrogates toward the goal of developing new sigma receptor imaging agents. en_US
dc.format.extent ix, 109 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2009 Freely available theses (MU) en_US
dc.subject.lcsh Sigma receptors en_US
dc.subject.lcsh Rhenium compounds en_US
dc.subject.lcsh Imaging systems in chemistry en_US
dc.subject.lcsh Cancer cells -- Proliferation en_US
dc.subject.lcsh Central nervous system -- Cancer en_US
dc.title Synthesis of rhenium complexes as models for new sigma receptor imaging agents en_US
dc.type Thesis en_US
thesis.degree.discipline Chemistry en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.oclc 703666966 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2009 Theses


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