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dc.contributor.authorPapoulias, Dianaeng
dc.contributor.authorVillalobos, Sergio A.eng
dc.contributor.authorMeadows, John C.eng
dc.contributor.authorNoltie, Douglas B. (Douglas Brian), 1958-eng
dc.contributor.authorGiesy, John P.eng
dc.contributor.authorTillitt, Donald (Donald Edward), 1957-eng
dc.date.issued2003-01eng
dc.descriptionReproduced with permission from Environmental Health Perspectives. doi:10.1289/ehp.5540eng
dc.description.abstractDespite being banned in many countries, dichlorodiphenyltrichloroethane (DDT) and its metabolites dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) continue to be found in fish tissues at concentrations of concern. Like o,p´-DDT, o,p´-DDE is estrogenic and is believed to exert its effects through binding to the estrogen receptor. The limited toxicologic data for o,p´-DDE suggest that it decreases fecundity and fertility of fishes. We conducted an egg injection study using the d-rR strain of medaka and environmentally relevant concentrations of o,p´-DDE to examine its effects on sexual differentiation and development. The gonads of exposed fish showed no evidence of sex reversal or intersex. However, other gonad abnormalities occurred in exposed individuals. Females exhibited few vitellogenic oocytes and increased atresia. Male testes appeared morphologically normal but were very small. Gonadosomatic index values for both sexes were lower for exposed fish. Our observations of abnormal female and very small male gonads after in ovo o,p´-DDE exposure may be indicative of effects on early endocrine processes important for normal ovarian and testicular development.eng
dc.identifier.citationPapoulias DM, Villalobos SA, Meadows J, Noltie DB, Giesy JP, et al. 2003 In Ovo Exposure to o,p´-DDE Affects Sexual Development But Not Sexual Differentiation in Japanese Medaka (Oryzias latipes). Environmental Health Perspectives 111:29-32.eng
dc.identifier.urihttp://hdl.handle.net/10355/10139eng
dc.languageEnglisheng
dc.publisherNational Institute of Environmental Health Scienceseng
dc.relation.ispartofcollectionFisheries and Wildlife Sciences publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. College of Agriculture, Food and Natural Resources. School of Natural Resources. Department of Fisheries and Wildlife Scienceseng
dc.source.harvestedEnvironmental Health Perspectives Web siteeng
dc.subject.lcshInsecticideseng
dc.subject.lcshOryzias latipes -- Fertilityeng
dc.subject.lcshSex differentiationeng
dc.titleIn Ovo Exposure to o,p´-DDE Affects Sexual Development But Not Sexual Differentiation in Japanese Medaka (Oryzias latipes)eng
dc.typeArticleeng


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