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dc.contributor.authorWindham, Gayle C.eng
dc.contributor.authorWaller, Kirsteneng
dc.contributor.authorAnderson, Mereditheng
dc.contributor.authorFenster, Lauraeng
dc.contributor.authorMendola, Paulineeng
dc.contributor.authorSwan, Shanna H.eng
dc.date.issued2003-06eng
dc.descriptionReproduced with permission from Environmental Health Perspectives. doi:10.1289/ehp.5922eng
dc.description.abstractWe analyzed data from a prospective study of menstrual cycle function and early pregnancy loss to explore further the effects of trihalomethanes (THM) on reproductive end points. Premenopausal women collected urine samples daily during an average of 5.6 cycles for measurement of steroid metabolites that were used to define menstrual parameters such as cycle and phase length. Women were asked about consumption of various types of water as well as other habits and demographics. We found a monotonic decrease in mean cycle length with increasing total THM (TTHM) level. This finding was also reflected as a reduced follicular phase length. A decrement in cycle and follicular phase length of per 10 µg/L unit increase in TTHM concentration was found. There was little association with luteal phase length, menses length, or cycle variability. Examining the individual THMs by quartile, we found the greatest association with chlorodibromomethane or the sum of the brominated compounds. Incorporating tap water consumption showed a similar pattern of reduced cycle length with increasing TTHM exposure. These findings suggest that THM exposure may affect ovarian function and should be confirmed in other studies.eng
dc.identifier.citationWindham GC, Waller K, Anderson M, Fenster L, Mendola P, et al. 2003 Chlorination By-Products in Drinking Water and Menstrual Cycle Function. Environmental Health Perspectives 111(7): 935-941.eng
dc.identifier.urihttp://hdl.handle.net/10355/10163eng
dc.languageEnglisheng
dc.publisherNational Institute of Environmental Health Scienceseng
dc.relation.ispartofFamily and Community Medicine publications (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. School of Medicine. Department of Family and Community Medicineeng
dc.source.harvestedEnvironmental Health Perspectives Web siteeng
dc.subject.lcshTrihalomethaneseng
dc.subject.lcshMenstrual cycleeng
dc.subject.lcshReproductive healtheng
dc.subject.lcshDrinking water -- Health aspectseng
dc.titleChlorination By-Products in Drinking Water and Menstrual Cycle Functioneng
dc.typeArticleeng


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