Exposure Assessment for Endocrine Disruptors: Some Considerations in the Design of Studies

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Exposure Assessment for Endocrine Disruptors: Some Considerations in the Design of Studies

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/10167

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Title: Exposure Assessment for Endocrine Disruptors: Some Considerations in the Design of Studies
Author: Rice, Carol Helen; Birnbaum, Linda S.; Cogliano, Vincent James; Mahaffey, Kathryn R., 1943-; Needham, Larry L.; Rogan, Walter J.; vom Saal, Frederick S.
Keywords: chemical exposure
Date: 2003-10
Publisher: National Institute of Environmental Health Sciences
Citation: Rice C, Birnbaum LS, Cogliano J, Mahaffey K, Needham L, et al. 2003 Exposure Assessment for Endocrine Disruptors: Some Considerations in the Design of Studies. Environmental Health Perspectives 111(13): 1683-1690.
Abstract: In studies designed to evaluate exposure-response relationships in children's development from conception through puberty, multiple factors that affect the generation of meaningful exposure metrics must be considered. These factors include multiple routes of exposure; the timing, frequency, and duration of exposure; need for qualitative and quantitative data; sample collection and storage protocols; and the selection and documentation of analytic methods. The methods for exposure data collection and analysis must be sufficiently robust to accommodate the a priori hypotheses to be tested, as well as hypotheses generated from the data. A number of issues that must be considered in study design are summarized here.
URI: http://hdl.handle.net/10355/10167

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