Meeting Report: Batch-to-Batch Variability in Estrogenic Activity in Commercial Animal Diets—Importance and Approaches for Laboratory Animal Research

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Meeting Report: Batch-to-Batch Variability in Estrogenic Activity in Commercial Animal Diets—Importance and Approaches for Laboratory Animal Research

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/10169

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dc.contributor.author Heindel, Jerrold J.
dc.contributor.author vom Saal, Frederick S.
dc.date.accessioned 2011-03-09T16:27:05Z
dc.date.available 2011-03-09T16:27:05Z
dc.date.issued 2008-03
dc.identifier.citation Heindel JJ, vom Saal FS, 2007 Meeting Report: Batch-to-Batch Variability in Estrogenic Activity in Commercial Animal Diets—Importance and Approaches for Laboratory Animal Research. Environmental Health Perspectives 116(3): 389-393. en_US
dc.identifier.uri http://hdl.handle.net/10355/10169
dc.description Reproduced with permission from Environmental Health Perspectives. doi:10.1289/ehp.10524 en_US
dc.description.abstract We report information from two workshops sponsored by the National Institutes of Health that were held to a) assess whether dietary estrogens could significantly impact end points in experimental animals, and b) involve program participants and feed manufacturers to address the problems associated with measuring and eliminating batch-to-batch variability in rodent diets that may lead to conflicting findings in animal experiments within and between laboratories. Data were presented at the workshops showing that there is significant batch-to-batch variability in estrogenic content of commercial animal diets, and that this variability results in differences in experimental outcomes. A combination of methods were proposed to determine levels of total estrogenic activity and levels of specific estrogenic constituents in soy-containing, casein-containing, and other soy-free rodent diets. Workshop participants recommended that researchers pay greater attention to the type of diet being used in animal studies and choose a diet whose estrogenic activity (or lack thereof) is appropriate for the experimental model and end points of interest. Information about levels of specific phytoestrogens, as well as estrogenic activity caused by other contaminants and measured by bioassay, should be disclosed in scientific publications. This will require laboratory animal diet manufacturers to provide investigators with information regarding the phytoestrogen content and other estrogenic compounds in commercial diets used in animal research. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.ispartof Biological Sciences publications (MU)
dc.subject.lcsh Laboratory animals -- Feeding and feeds en_US
dc.subject.lcsh Food -- Estrogen content en_US
dc.subject.lcsh Biological assay en_US
dc.title Meeting Report: Batch-to-Batch Variability in Estrogenic Activity in Commercial Animal Diets—Importance and Approaches for Laboratory Animal Research en_US
dc.type Article en_US
dc.source.harvested Environmental Health Perspectives Web site. en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. College of Arts and Sciences. Division of Biological Sciences


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