In patients experiencing acute pain, how does the efficacy and gastrointestinal tolerability of tapentadol compare with oxycodone?
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The analgesic effect of tapentadol (Nucynta®) immediate release (IR) 50 and 75 mg are comparable to oxycodone IR 10 mg, and tapentadol IR 100 mg to oxycodone IR 15 mg, for the treatment of acute pain. Tapentadol is associated with less nausea or vomiting than oxycodone at equianalgesic doses. (SOR: B, based on evidence from RCTs.)
Evidence Based Practice 14(3): 14.