For patients with glucose intolerance, what medications reduce the risk of developing type 2 diabetes?
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Metformin (SOR: A, based on consistent RCTs) or acarbose (SOR: B, based on a single RCT) are likely to be effective for preventing or delaying the onset of diabetes compared with placebo. However, the most effective intervention remains lifestyle modification (SOR: A, based on a consistent RCT).
Evidence Based Practice 14(3): 09-10.