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GAL1-SceI directed site-specific genomic (gsSSG) mutagenesis: a method for precisely targeting point mutations in S. cerevisiae.
(2011-12-05)
Abstract
Background
Precise targeted mutations are defined as targeted mutations that do not require the retention of other genetic changes, such as marker genes, near the mutation site. In the yeast, S. cerevisiae, ...
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma
(2011-04-18)
Abstract
Background
Mycoparasitism, a lifestyle where one fungus is parasitic on another fungus, has special relevance when the prey is a plant pathogen, providing a strategy for biological control of pests for plant ...
Investment into the future of microbial resources: culture collection funding models and BRC business plans for biological resource centres
(2014-02-12)
Through their long history of public service, diverse microbial Biological Resource Centres (mBRCs) have made myriad contributions to society and science. They have enabled the maintenance of specimens isolated before ...
CPP-ZFN: A potential DNA-targeting anti-malarial drug
(2010-09-16)
Abstract
Background
Multidrug-resistant Plasmodium is of major concern today. Effective vaccines or successful applications of RNAi-based strategies for the treatment of malaria are currently unavailable. An unexplored ...
The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity
(2011-09-27)
Abstract
Background
The fungal pathogen Candida albicans is frequently seen in immune suppressed patients, and resistance to one of the most widely used antifungals, fluconazole (FLC), can evolve rapidly. In recent years ...
A unified phylogeny-based nomenclature for histone variants
(2012-05-31)
AbstractHistone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions ...
Diabetes (db/db) mutation-induced endometrial epithelial lipoapoptosis: Ultrastructural and cytochemical analysis of reproductive tract atrophy
(2005-04-27)
Abstract
Background
The diabetes (db/db) mutation in C57BL/KsJ mice promotes a progressive cytolipidemia within the endometrial ...
Influences of obese (ob/ob) and diabetes (db/db) genotype mutations on lumber vertebral radiological and morphometric indices: Skeletal deformation associated with dysregulated systemic glucometabolism
(2006-02-01)
Abstract
Background
Both diabetes and obesity syndromes are recognized to promote lumbar vertebral instability, premature ...
Site-specific genomic (SSG) and random domain-localized (RDL) mutagenesis in yeast
(2004-04-16)
Abstract
Background
A valuable weapon in the arsenal available to yeast geneticists is the ability to introduce specific mutations ...
Global catalogue of microorganisms (gcm): a comprehensive database and information retrieval, analysis, and visualization system for microbial resources
(2013-12-30)
Abstract
Background
Throughout the long history of industrial and academic research, many microbes have been isolated, characterized and preserved (whenever possible) in culture collections. With ...