dc.contributor.advisor | Smith, George P., 1941- | eng |
dc.contributor.author | Thomas, William Donald, 1974- | eng |
dc.date.issued | 2010 | eng |
dc.date.submitted | 2010 Fall | eng |
dc.description | Title from PDF of title page (University of Missouri--Columbia, viewed on March 8, 2011). | eng |
dc.description | The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. | eng |
dc.description | Dissertation advisor: Dr. George P. Smith. | eng |
dc.description | Vita. | eng |
dc.description | Ph. D. University of Missouri--Columbia 2010. | eng |
dc.description.abstract | [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Approximately 30% of breast cancers are linked with the over-expression of ErbB2. Because of its critical role in signal transduction, the progression of breast cancer and its localization on the surface of several types of cancer cells, ErbB2 is a commonly used as a target for the search for protein and peptide ligands that may be useful as therapeutic and diagnostic agents for treating and imaging cancer. In the work described here, I used several commonly used in vitro, ex vivo, and in vivo phage display techniques and binding assays in an attempt to discover such peptides. This work lead to the discovery a phage mutant which interferes with the usage of the phage display libraries of the type used during this research. In addition, I also report the results of a quantitative assessment of a new enzymatically releasable phage construct. | eng |
dc.description.bibref | Includes bibliographical references. | eng |
dc.format.extent | 43 pages | eng |
dc.identifier.merlin | b81832977 | eng |
dc.identifier.oclc | 709593495 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/10348 | |
dc.identifier.uri | https://doi.org/10.32469/10355/10348 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | Access is limited to the campuses of the University of Missouri. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | |
dc.subject.lcsh | Tumor proteins | eng |
dc.subject.lcsh | Bacteriophages | eng |
dc.subject.lcsh | HER-2 protein | eng |
dc.subject.lcsh | HER-2 gene | eng |
dc.subject.lcsh | Breast -- Cancer | eng |
dc.title | In vitro and in vivo approaches to tumor targeting by phage display | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Biological sciences (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |