What is the relative efficacy of H2 blockers and PPIs in treating patients with reflux symptoms?
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H2-receptor antagonists (H2RAs) and proton-pump inhibitors (PPIs) are both effective in the treatment of reflux symptoms when compared with placebo. PPIs are at least twice as effective as H2RAs in achieving remission in the empiric treatment of heartburn and in the treatment of endoscopic-negative reflux disease (ENRD). Treatment with twice-daily PPIs is slightly more effective than once-daily PPIs in the treatment of reflux symptoms among patients with esophagitis (all statements SOR: A, based on meta-analyses).
Evidence Based Practice 14(4): 06.