What is the most effective treatment for restless legs syndrome (RLS)?
Metadata[+] Show full item record
Head-to-head RCTs for the 2 therapeutic agents approved by the US Food and Drug Administration (FDA) for RLS—ropinirole and pramipexole—are lacking. However, pramipexole appears to be more efficacious and may be better tolerated. (SOR: B, based on an “indirect” meta-analysis of placebo comparison trials.)
Evidence Based Practice 14(4): 09-10.