Dosing enoxaparin for DVT prophylaxis in morbidly obese patients
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Evidence is currently limited on the optimal dosing and frequency of chemoprophylaxis for deep vein thrombosis (DVT) in the morbidly obese hospitalized patient. Increasingly, low-molecular-weight heparin (LMWH) is dosed BID in these patients. One cohort study, conducted in patients with a body mass index (BMI) above 50 kg/m2 undergoing bariatric surgery, found that LMWH 40 mg every 12 hours resulted in fewer DVT or PE events than 30 mg every 12 hours, without increasing bleeding events.
Evidence Based Practice 14(4): 13.