Dosing enoxaparin for DVT prophylaxis in morbidly obese patients
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Evidence is currently limited on the optimal dosing and frequency of chemoprophylaxis for deep vein thrombosis (DVT) in the morbidly obese hospitalized patient. Increasingly, low-molecular-weight heparin (LMWH) is dosed BID in these patients. One cohort study, conducted in patients with a body mass index (BMI) above 50 kg/m2 undergoing bariatric surgery, found that LMWH 40 mg every 12 hours resulted in fewer DVT or PE events than 30 mg every 12 hours, without increasing bleeding events.
Evidence-based practice 14, no. 04 (2011): 13