Browsing 2011 UMKC Dissertations - Freely Available Online by Thesis Advisor "Mitra, Ashim K., 1954-"
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Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)Controlled drug delivery utilizing novel biodegradable and biocompatible pentablock copolymers could be a valuable strategy for the treatment of chronic eye diseases. In attempts to achieve controlled drug release, various ... -
Formulation of nanoparticles encapsulating hydrophilic molecules following their ionic complexation
(University of Missouri--Kansas City, 2011-06-01)Part 1: Dexamethasone is one of the most widely used drug molecules for the treatment of posterior segment ocular diseases. The major problems associated with the delivery of dexamethasone include its poor aqueous solubility ... -
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ... -
Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
(University of Missouri-Kansas City, 2011-12-21)Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of the most common infectious diseases causing corneal blindness in the United States. In this study, polymeric nanoparticles ...