Browsing 2011 UMKC Dissertations - Freely Available Online by Thesis Department "Pharmacy (UMKC)"
Now showing items 1-7 of 7
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Development and evaluation of novel in situ depot-forming controlled release formulations
(University of Missouri--Kansas City, 2011-10-24)Controlled drug delivery utilizing novel biodegradable and biocompatible pentablock copolymers could be a valuable strategy for the treatment of chronic eye diseases. In attempts to achieve controlled drug release, various ... -
Formulation of nanoparticles encapsulating hydrophilic molecules following their ionic complexation
(University of Missouri--Kansas City, 2011-06-01)Part 1: Dexamethasone is one of the most widely used drug molecules for the treatment of posterior segment ocular diseases. The major problems associated with the delivery of dexamethasone include its poor aqueous solubility ... -
Indole Arynes in organic synthesis : discovery and applications for the total synthesis of complex natural products
(University of Missouri -- Kansas City, 2011-05-03)Arynes and heteroarynes are very important and useful reactive intermediates with many applications in organic synthesis, including natural products total synthesis. Although benzyne, the parent and most famous aryne, has ... -
Part I: The synthesis of chenodeoxycholic acid derived macrocyles and cage compounds. Part II. Sonogashira coupling for the synthesis of well-defined π-conjugated arylene ethynylene oligomers as blue-light-emitting materials
(University of Missouri--Kansas City, 2012-01-20)The design and development of novel chenodeoxychoic acid (CDCA) derivatives and its molecular architecture was accomplished. A novel CDCA derivative with an ambient CO2 insertion to 7α-side chain has been serendipitously ... -
Structural and chemical studies of RNA as anti-cancer target and signaling molecule
(University of Missouri--Kansas City, 2012-01-06)Ribonucleic acids have been found to have a major role in causation and propagation of diseases. Targeting such therapeutically important RNA can be a method of treatment of various diseases. Two such therapeutically ... -
Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
(University of Missouri-Kansas City, 2011-12-21)Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of the most common infectious diseases causing corneal blindness in the United States. In this study, polymeric nanoparticles ... -
Synthesis, morphologies and applications of polyoxometalate-containing diblock copolymers
(University of Missouri--Kansas City, 2012-01-31)Block copolymers by virtue of their ability to self assemble and microphaseseparation due to the contrast in chemical and physical properties of the covalently linked blocks constitute the essential building blocks towards ...