What are the risks of long-acting beta-agonist (LABA) use in patients with asthma?
Two recent meta-analyses have conflicting results. One found an increased risk of asthma-related intubation and death when LABAs are used alone or in combination with inhaled corticosteroids (ICS). A second systematic review found improved asthma-related outcomes when adding LABAs to ICS in adult patients with inadequately controlled asthma. These reviews differed in their primary endpoints and inclusion criteria.
Evidence Based Practice 14(5): 09.