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    • Graduate School - MU Theses and Dissertations (MU)
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    • 2009 Dissertations (MU)
    • 2009 MU dissertations - Freely available online
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    Computational neural models at molecular, cellular and behavioral levels : three case studies

    Mohan, Ashwin, 1978-
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    Date
    2009
    Format
    Thesis
    Metadata
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    Abstract
    Biological findings from molecular, cellular and behavior levels can be difficult to understand functions. Computational tools and systems concepts facilitate integration of information across levels to further understanding of functional level issues. This integration is eventually formalized as experimentally accessible models that facilitate visualization of the system as a whole. At the molecular level, a computational model of the synapse was used to study cellular adaptations after cocaine addiction. The molecular diffusion model was used to propose feasible glial geometries to study the role of diffusion path length on synaptic isolation. At the network level, a biophysical network model of the basal amygdala was developed to investigate interconnectivity between cellular nuclei to produce three types of cells observed after auditory fear conditioning. At the behavior level, a computational model of rapid signaler-receiver interactions in this group-living insect was developed to study the emergence of informative global patterns by providing interacting individuals with local cues.
    URI
    https://hdl.handle.net/10355/10761
    https://doi.org/10.32469/10355/10761
    Degree
    Ph. D.
    Thesis Department
    Electrical and computer engineering (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • Electrical Engineering and Computer Science electronic theses and dissertations (MU)
    • 2009 MU dissertations - Freely available online

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