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dc.contributor.advisorFolk, William Roberteng
dc.contributor.advisorGangopadhyay, Shubhraeng
dc.contributor.authorBok, Sangho, 1972-eng
dc.date.issued2010eng
dc.date.submitted2010 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on October 21, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. William Folk and Dr. Shubhra Gangopadhyay.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia 2010.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Nanomaterials have gained importance in virtually all fields from industrial applications to pure science research since these were developed. However, synthesis and characterization of these nanomaterials are not trivial nor fully understood. This thesis focuses on the synthesis and characterization of nanostructures/nanomaterials and their applications. First, properties of nanostructures prepared with sol-gel chemistry and carbon based materials leading to supercapacitors with unique hydrophobic/hydrophilic structure have been studied. Second, fluorescent dye-doped nanoparticles prepared from organosilicate polymers, poly-methylsilsesquioxane (PMSSQ), as small as 3.5nm and as large as 50nm, have been synthesized which exhibit very intense fluorescence as well as excellent photo-stability. Surface modified nanoparticles were used for conjugation with proteins. The conjugated nanoparticle-protein complexes have been characterized with respect to the number of dye molecules per protein, biological activity and sensitivity of detection of ligands. Third, specificity and sensitivity of the nanoparticle-protein complexes in immunofluorescence assays have been used to image fibronectin in chick heart, resulting in three orders of magnitude enhancement of detection compared to commercial dye-labeled antibody. Finally, progress in the development of a dipstick assay for detection of corticosteroid binding globulin (CBG) bound to cortisol has been achieved, which will be used for a simple and robust diagnostic device being able to measure the ratio of cortisol to 6[beta]-hydroxycortisol as an in vivo indicator of induction of an enzyme, cytochrome P450 3A4 (CYP3A4).eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentx, 119 pageseng
dc.identifier.merlinb82634841eng
dc.identifier.oclc657112399eng
dc.identifier.urihttps://hdl.handle.net/10355/10918
dc.identifier.urihttps://doi.org/10.32469/10355/10918eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshSupercapacitorseng
dc.subject.lcshNanostructured materials -- Synthesiseng
dc.subject.lcshImmunofluorescenceeng
dc.titleSynthesis and characterization of nanostructures and their applications : from supercapacitors to fluorescent labels to proteinseng
dc.typeThesiseng
thesis.degree.disciplineElectrical and computer engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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