Adding pieces to the monocytic ehrlichiosis puzzle: treatment, etiology and protection with a canine model
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[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Infections with Ehrlichia canis cause Canine Monocytic Ehrlichiosis (CME), a disease which causes morbidity and mortality of dogs worldwide. Currently, there are questions in the literature regarding efficacy of treatment, etiology of severe disease and whether previous infections offer protection to dogs when they are challenged. Through careful experimentation it was determined that although treatment with doxycycline successfully ameliorates disease, it is not sufficient to clear bacteria from infected dogs and therefore a different treatment regimen should be explored which would fully clear the bacteria. Furthermore, it was determined that E. canis alone could induce severe acute CME in specific pathogen free dogs. Lastly, dogs were infected with E. canis, treated and then given a homologous challenge. Although the dogs demonstrated less severe signs of disease three out of four had levels of bacteria in their blood higher than what was seen during the initial infection.
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