Impaired spatial learning and increased locomotor activity in TgCRND8 mice as a model of Alzheimer's disease

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Impaired spatial learning and increased locomotor activity in TgCRND8 mice as a model of Alzheimer's disease

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/10938

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dc.contributor.advisor Schachtman, Todd R. en_US
dc.contributor.author Walker, Jennifer M., 1985- en_US
dc.date.accessioned 2011-06-10T13:56:27Z
dc.date.available 2011-06-10T13:56:27Z
dc.date.issued 2010 en_US
dc.date.submitted 2010 Spring en_US
dc.identifier.other WalkerJ-051010-T4482 en_US
dc.identifier.uri http://hdl.handle.net/10355/10938
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on November 3, 2010). en_US
dc.description The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. en_US
dc.description Thesis advisor: Dr. Todd R. Schachtman. en_US
dc.description Includes bibliographical references. en_US
dc.description M. A. University of Missouri--Columbia 2010. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Psychology. en_US
dc.description.abstract This study provides a behavioral characterization of the TgCRND8 mouse strain, an APP (double-mutant) transgenic model of Alzheimer's disease (AD). While past research focused mainly on 2-5 month-old TgCRND8 mice, this study used an older age cohort (8-9 months old), in addition to a 4 month-old cohort of both transgenic and wild-type female mice. Performance was assessed using three behavioral measures: touch escape, the Barnes maze, and an open-field test. No differences in irritability were found between Tg and control mice in the younger cohort; however, older Tg mice displayed significantly higher irritability compared to wildtype littermates, as measured by the touch escape test. Both younger and older transgenic mice displayed poor spatial learning in the Barnes maze task compared to their wildtype littermates, as demonstrated by significantly longer latencies and more errors both during acquisition and at 2- week retest. Additionally, Tg mice of both cohorts showed increased long-term (60 min) locomotion in the open-field test. en_US
dc.format.extent vi, 33 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2010 Freely available theses (MU) en_US
dc.subject.lcsh Transgenic mice -- Behavior en_US
dc.subject.lcsh Alzheimer's disease -- Animal models en_US
dc.subject.lcsh Spatial behavior in animals en_US
dc.subject.lcsh Locomotion -- Regulation en_US
dc.title Impaired spatial learning and increased locomotor activity in TgCRND8 mice as a model of Alzheimer's disease en_US
dc.type Thesis en_US
thesis.degree.discipline Psychology en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.A. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin b82432247
dc.identifier.oclc 729916539 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2010 Theses


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