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dc.contributor.advisorSchachtman, Todd R.en_US
dc.contributor.authorWalker, Jennifer M., 1985-en_US
dc.date.issued2010eng
dc.date.submitted2010 Springen_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on November 3, 2010).en_US
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.en_US
dc.descriptionThesis advisor: Dr. Todd R. Schachtman.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionM. A. University of Missouri--Columbia 2010.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Psychology.en_US
dc.description.abstractThis study provides a behavioral characterization of the TgCRND8 mouse strain, an APP (double-mutant) transgenic model of Alzheimer's disease (AD). While past research focused mainly on 2-5 month-old TgCRND8 mice, this study used an older age cohort (8-9 months old), in addition to a 4 month-old cohort of both transgenic and wild-type female mice. Performance was assessed using three behavioral measures: touch escape, the Barnes maze, and an open-field test. No differences in irritability were found between Tg and control mice in the younger cohort; however, older Tg mice displayed significantly higher irritability compared to wildtype littermates, as measured by the touch escape test. Both younger and older transgenic mice displayed poor spatial learning in the Barnes maze task compared to their wildtype littermates, as demonstrated by significantly longer latencies and more errors both during acquisition and at 2- week retest. Additionally, Tg mice of both cohorts showed increased long-term (60 min) locomotion in the open-field test.en_US
dc.format.extentvi, 33 pagesen_US
dc.identifier.merlinb82432247
dc.identifier.oclc729916539en_US
dc.identifier.otherWalkerJ-051010-T4482en_US
dc.identifier.urihttp://hdl.handle.net/10355/10938
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2010 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2010 Theses
dc.subject.lcshTransgenic mice -- Behavioren_US
dc.subject.lcshAlzheimer's disease -- Animal modelsen_US
dc.subject.lcshSpatial behavior in animalsen_US
dc.subject.lcshLocomotion -- Regulationen_US
dc.titleImpaired spatial learning and increased locomotor activity in TgCRND8 mice as a model of Alzheimer's diseaseen_US
dc.typeThesisen_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.disciplinePsychologyeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelMastersen_US
thesis.degree.nameM.A.en_US


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