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dc.contributor.advisorSchachtman, Todd R.eng
dc.contributor.authorWalker, Jennifer M., 1985-eng
dc.date.issued2010eng
dc.date.submitted2010 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on November 3, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. Todd R. Schachtman.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM. A. University of Missouri--Columbia 2010.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Psychology.eng
dc.description.abstractThis study provides a behavioral characterization of the TgCRND8 mouse strain, an APP (double-mutant) transgenic model of Alzheimer's disease (AD). While past research focused mainly on 2-5 month-old TgCRND8 mice, this study used an older age cohort (8-9 months old), in addition to a 4 month-old cohort of both transgenic and wild-type female mice. Performance was assessed using three behavioral measures: touch escape, the Barnes maze, and an open-field test. No differences in irritability were found between Tg and control mice in the younger cohort; however, older Tg mice displayed significantly higher irritability compared to wildtype littermates, as measured by the touch escape test. Both younger and older transgenic mice displayed poor spatial learning in the Barnes maze task compared to their wildtype littermates, as demonstrated by significantly longer latencies and more errors both during acquisition and at 2- week retest. Additionally, Tg mice of both cohorts showed increased long-term (60 min) locomotion in the open-field test.eng
dc.format.extentvi, 33 pageseng
dc.identifier.merlinb82432247eng
dc.identifier.oclc729916539eng
dc.identifier.otherWalkerJ-051010-T4482eng
dc.identifier.urihttp://hdl.handle.net/10355/10938eng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2010 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2010 Theseseng
dc.subject.lcshTransgenic mice -- Behavioreng
dc.subject.lcshAlzheimer's disease -- Animal modelseng
dc.subject.lcshSpatial behavior in animalseng
dc.subject.lcshLocomotion -- Regulationeng
dc.titleImpaired spatial learning and increased locomotor activity in TgCRND8 mice as a model of Alzheimer's diseaseeng
dc.typeThesiseng
thesis.degree.disciplinePsychology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.A.eng


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