PSA testing: When it's useful, when it's not
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Do not routinely screen all men over the age of 50 for prostate cancer with the prostate-specific antigen (PSA) test. Consider screening men younger than 75 with no cardiovascular or cancer risk factors -- the only patient population for whom PSA testing appears to provide even a small benefit. Strength of recommendation B: Based on a meta-analysis of 6 randomized controlled trials (RCTs) with methodological limitations, and a post hoc analysis of a large RCT.
Journal of Family Practice, 50(6) 2011: 357-360.