What cold sore medication is most effective at speeding resolution?
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Of the oral antiviral medications, famciclovir showed the quickest time to healing (2 days sooner than placebo). Among topical treatments available in the United States, zinc oxide cream showed the quickest time to healing (1.5 days sooner than placebo), although the studies for 1% penciclovir cream and 10% docosanol cream (each 0.7 days sooner than placebo) are of higher quality. (SOR: B, based on a comparison of placebo-controlled trials.)
Evidence Based Practice 14(7): 07.