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dc.contributor.advisorSpain, James Nobles, 1962-eng
dc.contributor.authorChamberlin, William Gleneng
dc.date.issued2011eng
dc.date.submitted2011 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 26, 2011).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. James N. Spain.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.S. University of Missouri--Columbia 2011.eng
dc.description.abstractWe hypothesized that cows with subclinical hypocalcemia at calving would have greater elevations in liver associated biochemical parameters and non-esterified fatty acid (NEFA) concentrations compared to normocalcemic cows. One hundred multiparous Holstein cows were assigned to one of two groups 1) normocalcemic (n=49; ionized calcium [iCa] ! 1.0 mmol/L) or 2) hypocalcemic (n=51; [iCa] [less than 1.0 mmol/L) based on whole blood [iCa] on the day of calving. Blood samples were collected from all cows for measurement of [iCa], NEFA concentrations, and plasma chemistry profiles at days -14, 0 (calving), 3, 7, 14, 21, and 35. On day 0, hypocalcemic cows had lower [iCa] than normocalcemic cows (P [less than] 0.001) and lower total plasma Ca (P [less than] 0.001). Hypocalcemic cows had lower plasma phosphorus concentrations on days 0 (P = 0.002), 7 (P = 0.05), 14 (P = 0.03), and 21 (P = 0.04). Hypocalcemic cows had higher NEFA concentrations on days 0 (P = 0.01) and 21 (P = 0.02). Hypocalcemic cows also tended to have higher NEFA concentrations on day 14 (P = 0.12). Hypocalcemic cows had more lipid in the hepatocytes on day 35 (P = 0.0008). No differences were detected between groups for total or direct bilirubin concentration, gamma glutamyl transferase or aspartate aminotransferase activity (P [greater than] 0.05). These data provide evidence of an association between calcium status at calving, fat mobilization, and liver lipid infiltration.eng
dc.format.extentix, 126 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/11161
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshHypocalcemiaeng
dc.subject.lcshDairy cattle -- Diseases -- Nutritional aspectseng
dc.subject.lcshCalcium -- Metabolism -- Disorderseng
dc.titleInfluence of subclinical hypocalcemia on plasma biochemical parameters, liver histologic changes, and common postpartum diseases in dairy cowseng
dc.typeThesiseng
thesis.degree.disciplineAnimal sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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