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dc.contributor.advisorCoates, Joan R.eng
dc.contributor.authorVasquez, Lauraeng
dc.date.issued2011eng
dc.date.submitted2011 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on August 24, 2011).eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis advisor: Joan R. Coates.eng
dc.description"May 2011"eng
dc.descriptionM.S. University of Missouri-Columbia 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.eng
dc.description.abstractMotor unit number estimation (MUNE) is an electrophysiologic technique for quantifying the lower motor neuron (LMN) system. MUNE has proven useful in evaluating and monitoring neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Recently a missense mutation in the canine superoxide dismutase 1 (SOD1) gene has been shown to be a risk factor for canine degenerative myelopathy (DM) suggesting homology to familial SOD1 ALS. To date, the LMN component of DM has not been well characterized or quantified. The modified incremental stimulation MUNE technique was applied to the sciatic-deep peroneal nerve branch with bilateral recordings at the extensor digitorum brevis muscle of 17 clinically normal dogs. Mean (± SD) value for the entire MUNE pool was 51 ± 21 with a range from 8 to 154. No statistically significant difference was noted between pelvic limbs (P=0.14) or between different age groups (< 7years old or >= 7 years old) (P=0.17). Test-retest reliability was assessed for trials performed under different anesthetic episodes (intermittent) versus trials performed under the same anesthetic episode (consecutive). The intraclass correlation coefficients for consecutive and intermittent MUNE evaluations were 0.73 and 0.65, respectively. These results provide preliminary reference ranges for normal dogs and document the potential utility of EDB modified incremental stimulation MUNE for longitudinal monitoring of lower motor neuron loss in DM affected dogs.eng
dc.format.extentviii, 94 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/11520
dc.languageEnglisheng
dc.publisherUniversity of Missouri-Columbiaeng
dc.relation.ispartof2011 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2011Theseseng
dc.subject.lcshNervous system -- Degenerationeng
dc.subject.lcshDogs -- Diseaseseng
dc.subject.lcshMotor neurons -- Diseaseseng
dc.subject.lcshElectromyography -- Techniqueeng
dc.subject.lcshBiochemical markerseng
dc.titleDevelopment of a motor unit number estimation technique in normal dogs: a potential biomarker for canine degenerative myelopathyeng
dc.typeThesiseng
thesis.degree.disciplineVeterinary biomedical sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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