What are the risks of recurrent seizures in adults if seizure medications are stopped after a prolonged seizure-free period?
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The risk for seizure relapse is increased after discontinuation of antiepileptic drugs (AEDs), with rates ranging from 50% to 57% after 3 to 4 years. (SOR: B, extrapolated from cohort studies.) Patients with normal neurological examination results have a lower rate of recurrence than patients with abnormal results. Patient age, sex, age at seizure onset, duration of seizure, or partial versus generalized seizure are not related to relapse risk. (SOR: B, based on a single RCT with 1-year follow-up.)
Evidence Based Practice 14(9): 09-10.