Antibiotic Prophylaxis to Prevent Recurrent UTI in Children
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Antibiotic prophylaxis to prevent recurrent UTI may be considered in infants and children with or without vesicoureteral reflux (VUR) after a first UTI. (Strength of Recommendation [SOR]: B, based on inconsistent evidence from systematic reviews and one large randomized controlled trial [RCT]) The potential benefit of preventing recurrent UTI by antibiotic prophylaxis should be weighed against the risk of antimicrobial resistance with future infections. (SOR: B, based on inconsistent evidence from one systematic review and two RCTs) Accurate diagnosis of UTI followed by prompt treatment is recommended. (SOR: C, based on expert opinion)
American Family Physician, 84(2) 2004: -4.