Preventing Acute Mountain Sickness
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Gradual ascent is the most effective method for preventing acute mountain sickness. (Strength of Recommendation [SOR]: B, based on good-quality prospective and retrospective cohort studies.) Acetazolamide should be used to prevent acute mountain sickness in persons with a history of acute mountain sickness or when gradual ascent is not practical. (SOR: A, based on two randomized controlled trials [RCTs] and a meta-analysis of 15 RCTs.) Dexamethasone is effective in preventing acute mountain sickness, but adverse effects must be considered. (SOR: A, based on a meta-analysis of seven RCTs.) Ginkgo extract is not recommended for acute mountain sickness prophylaxis. (SOR: A, based on seven controlled trials.)
American Family Physician, 84(4) 2011: -400.