In morbidly obese adults, should antibiotic dosing regimens be adjusted to achieve the same level of effectiveness compared with normal-weight adults?
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Antibiotic pharmacology is altered in obese and morbidly obese patients. However, the effect varies according to the compound, so no general rules can be applied to dosing adjustment. In addition, the clinical outcomes of dose adjustments have not been studied.
Evidence Based Practice 14(11): 11.