What is a safe platelet count prior to invasive procedures?
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Epidural anesthesia and central line placement can be performed with platelet counts above 50,000/μL. (SOR: B, based on retrospective studies.) Lumbar puncture (LP) can be performed with platelet counts above 20,000/μL. (SOR: C, based on a retrospective study, case series, and expert opinion.) Additional common invasive procedures should have platelet counts above 50,000/μL. (SOR: C, based on expert opinion.)
Evidence Based Practice 14(11): 08.