[-] Show simple item record

dc.contributor.authorMcLaughlin, Mark F.en
dc.contributor.authorEngelbrecht, Hendrik P.en
dc.contributor.authorCutler, Cathy S.en
dc.contributor.authorJurisson, Silvia S. (Silvia Sabine)en
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researchen
dc.contributor.meetingnameSummer Undergraduate Research and Creative Achievements Forum (2007 : University of Missouri--Columbia)en
dc.date2007en
dc.date.issued2007eng
dc.descriptionAbstract only available; Images included in PDF that are absent in abstract description.en
dc.description.abstractHeart disease remains one of the leading causes of death in the United States. Improved, function-specific imaging agents promise to augment current diagnostic techniques, leading to better treatment and fewer deaths. Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) provide physiological rather than anatomical imaging systems. As such, they non-invasively probe tissue function with greater accuracy than other imaging techniques. Since functional abnormalities occur well before anatomical changes, these scans can lead to earlier diagnosis. In PET imaging, a directing agent binds to a positron-emitting material and carries the radioisotope to a specific tissue (in our project, the heart) where the isotope decays, emitting a positron. Current PET imaging agents, such as 18F, have short half-lives and must be administered at or near the production facility (cyclotron). However, one promising positron emitting radiometal, 68Ga (t1/2 = 68 minutes), comes from a Ge/Ga parent/daughter generator system. In such a generator system, a "parent isotope" (68Ge, t1/2 = 271 days) with a long half-life decays into a useful "daughter isotope" with a short half-life. Periodic elution provides the daughter isotope in high specific activity. In our case, 68Ge can be transported anywhere in the world, where it generates a viable PET agent without the constraint of an on-site cyclotron. Our work focused on Schiff base and aminothiolate ligand systems. Specifically, we bound, characterized, and analyzed the Sal2Phen, Acac2Pn, ATSM, and PTSM ligands with non-radioactive gallium on the milligram level. In future research, complexes will be created analogously on the radioactive level (nanogram or picogram quantities) and compared to their thoroughly characterized milligram-scale equivalent. The compounds will be tested for stability in a biological model before progressing to animal studies and, potentially, human drug testing. GaAcac2Pn GaSal2Phen GaATSM GaPTSMen
dc.identifier.urihttp://hdl.handle.net/10355/1222en
dc.languageen_USen
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researchen
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forum
dc.source.urihttp://undergradresearch.missouri.edu/forums-conferences/abstracts/abstract-detail.php?abstractid=en
dc.subjectSingle Photon Emission Computed Tomographyen
dc.subjectPositron Emission Tomographyen
dc.subjectheart diseaseen
dc.subjectmedical imagingen
dc.titleGa-Ga over 68Ga: Novel chelates for PET heart imaging [abstract]en
dc.typePresentationen


Files in this item

[PDF]

This item appears in the following Collection(s)

[-] Show simple item record