What is the safest antidepressant medication for use in pregnancy?
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In treating pregnant patients with depression, no single agent stands out as offering a clear safety advantage over another. The most consistently noted morbidity with maternal antidepressant use is preterm birth. Paroxetine may increase the risk of congenital cardiac malformations, but the data are inconsistent. (SOB: B, based on systematic review of cohort and case-control studies.) In general, antidepressant selection should be made based on patient and family history of a favorable response. (SOR: C, based on expert opinion.)
Evidence Based Practice 14(12): 09.