Recent Submissions

  • What is the role of C-reactive protein (CRP) in diagnosing neonatal sepsis? 

    Gauer, Robert; Hoke, Jason (Family Physicians Inquiries Network, 2012-12)
    A single CRP value cannot diagnose or predict serious bacterial infections (SBI) in neonates. However, serial negative CRP values rule out SBI with a high degree of certainty (SOR: A, prospective cohort studies).
  • What is the prevalence of vaginal dryness postpartum and what is the best treatment? 

    Adam, Patricia; Madlon-Kay, Diane J. (Family Physicians Inquiries Network, 2012-12)
    The prevalence of postpartum vaginal dryness ranges from 17% by physical exam to 46% by patient report. Breastfeeding doubles the risk of vaginal dryness. For patients requesting treatment, topical estrogens twice a week ...
  • At what point in a normal vaginal delivery should uterotonics be given? 

    Hurley, Matthew; Moore-Connelley, Marci (Family Physicians Inquiries Network, 2012-12)
    During a normal vaginal delivery, no significant differences in clinically important outcomes are noted if uterotonics are given either at delivery of the anterior shoulder or after delivery of the placenta (SOR: A, Cochrane ...
  • What are the benefits and harms of bedrest for complications of pregnancy? 

    University of Missouri-Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network. Evidence Based Practice. (Family Physicians Inquiries Network, 2012-12)
    Bedrest does not reduce the rate of miscarriage or preterm birth, nor does it improve outcomes in women with multiple pregnancies (SOR: A, meta-analyses). Evidence is insufficient to determine whether bedrest improves ...
  • Is uterine artery embolization (UAE) safe and effective for treatment of uterine fibroids? 

    University of Missouri-Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network. Evidence Based Practice. (Family Physicians Inquiries Network, 2012-12)
    Compared with hysterectomy or myomectomy, UAE for treating fibroids results in similar patient satisfaction. UAE is associated with fewer blood transfusions, shorter hospital stays, and quicker resumption of normal activities ...
  • Does tamoxifen prevent breast cancer? 

    Griffith, Denise (Family Physicians Inquiries Network, 2012-12)
    Tamoxifen reduces the incidence of breast cancer in women at increased risk for breast cancer and this benefit continues after treatment (SOR: A, multiple consistent RCTs). The risk of thromboembolic disease may double while ...
  • Should a 6-week-old infant exposed to chicken pox in a sibling receive varicella-zoster immune globulin (VZIG) or acyclovir? 

    Heinen, Joseph; Null, Danette B. (Family Physicians Inquiries Network, 2012-12)
    In an otherwise healthy 6-week-old infant exposed to chicken pox, the use of acyclovir or varicella-zoster immune globulin (VZIG) is not recommended, even though acyclovir does decrease the chance of infection (SOR: C, ...
  • What is the best approach to screening for hypoglycemia in normal newborn infants? 

    Partis, Kerry; Kachowski, Larisa; Over, Darrell R. (Family Physicians Inquiries Network, 2012-12)
    Hypoglycemia is defined as a plasma glucose level (PGL) less than the fifth percentile. Fifth percentile values in normal term newborns are 28, 40, and 48 mg/dL at 1 to 2, 3 to 47, and 48 to 72 hours of life, respectively ...
  • In low-risk pregnant women, does routine office urine dipstick proteinuria ≥30 mg/dL predict the development of preeclampsia? 

    Miller, Emily R.; Nunes, Natalie L.; Bartholomew, Betsy (Family Physicians Inquiries Network, 2012-12)
    Routine office urine dipstick for proteinuria in low-risk pregnant women does not predict the development of preeclampsia (SOR: B, systematic review of 3 cohort studies).
  • Do progestin-only hormonal contraceptive pills alter the frequency of migraine? 

    Oprea, Simona; Narciso, Philipp (Family Physicians Inquiries Network, 2012-12)
    The use of progesterone-only contraceptive pills decreases the frequency of migraine attacks and the duration of auras (SOR: B, single RCT and prospective study).
  • Is oral spironolactone effective for acne in women? 

    Ewing, Kristine; Samaan, Michael (Family Physicians Inquiries Network, 2012-12)
    Spironolactone is mentioned as a treatment option for acne in women in current dermatological guidelines (SOR: C, expert opinion), although a systematic review found the evidence insufficient to confirm a benefit.
  • Does osteopathic manipulative treatment (OMT) during pregnancy reduce delivery-related or postpartum complications? 

    Kramer, Matthew W.; Persons, Robert K. (Family Physicians Inquiries Network, 2012)
    OMT during pregnancy has been associated with decreased rates of meconium-stained amniotic fluid and preterm deliveries. OMT does not alter the risk of operative vaginal delivery or cesarean delivery (SOR: C, low-quality ...
  • What medicine best prevents migraines in children? 

    University of Missouri-Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network. Evidence Based Practice. (Family Physicians Inquiries Network, 2012-12)
    In children with recurrent migraines, propranolol, amitriptyline, topiramate, and valproic acid are all effective for reducing headache frequency, duration, and severity (SOR: B, RCT and cohort studies). Unfortunately, ...
  • What medications are safe and effective for heartburn during pregnancy? 

    Nguyen, Christine; Durant, Kacey; Flore, David (Family Physicians Inquiries Network, 2012-12)
    Antacids are effective for heartburn symptoms during pregnancy (SOR: B, small RCTs). The effects of H2 blocker and (proton pump inhibitor) PPI medications are not well studied. However, H2 blockers are likely safe. PPI ...
  • How effective are medications other than methylphenidate (Ritalin) for treatment of ADHD? 

    Evans, Patricia (Family Physicians Inquiries Network, 2012-12)
    Amphetamine formulations, methylphenidate, and atomoxetine are effective for the treatment of attention deficit with hyperactivity disorder (ADHD), with amphetamines probably more effective than methylphenidate, and ...
  • Intro to family health 

    Neher, Jon O. (Family Physicians Inquiries Network, 2012-12)
    In this letter the editor of Evidence Based Practice reminisces about childhood events which were his introduction to 'family health.'
  • Can imipramine be used for attention deficit disorder? 

    Engelhardt, Mary; Burch, Jessie; Onysko, Mary (Family Physicians Inquiries Network, 2012-12)
    Few well-controlled studies have evaluated imipramine for the treatment of attention deficit disorder (ADD); however, its major active metabolite, desipramine, is effective in the treatment of ADD (SOR: A, multiple consistent ...
  • What is the best imaging method for locating the missing testis in a toddler with clinical cryptorchidism? 

    Cohen, Andy; Sharma, Umang (Family Physicians Inquiries Network, 2012-12)
    Physicians should use ultrasound (US), magnetic resonance imaging (MRI), or magnetic resonance arteriography/venography (MRA/MRV) cautiously in the work-up of cryptorchidism, as their utility remains unclear. These methods ...
  • How soon after a vasectomy is it okay to have unprotected intercourse? 

    Edwards, Marjorie Antenor; Hudson, Jonell; Coulter, Lois (Family Physicians Inquiries Network, 2012-12)
    There is a large degree of variability in the length of time and number of ejaculations to attain azoospermia after a vasectomy. It appears that azoospermia is achieved in 80% of men after an average of 3-4 months and a ...
  • How does montelukast compare with inhaled corticosteroids for the control of mild to moderate persistent asthma in children? 

    Retailliau, Lise; Brennan, Michal (Family Physicians Inquiries Network, 2012-12)
    Inhaled corticosteroids (ICS) are more effective than montelukast in treating mild to moderate persistent asthma and are the preferred therapy; montelukast may be considered as an adjunctive treatment (SOR: A, consistent ...

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