What is the most effective first-line medical treatment of patients with primary Raynaud's phenomenon?
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Nifedipine is the most effective calcium-channel blocker (CCB) for treating primary Raynaud's phenomenon and is usually dosed at 5 to 20 mg 3 times daily. (SOR: B, based on a meta-analysis of lower-quality clinical trials.) Non-CCB vasodilators do not appear to be effective. (SOR: B, based on a meta-analysis of lower-quality clinical trials.)
Evidence Based Practice 15(1): 08-09.