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dc.contributor.authorWolf, Markeng
dc.contributor.authorZhang, Xiulieng
dc.contributor.authorQuinn, Thomas P. (Thomas Patrick), 1961-eng
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researcheng
dc.contributor.meetingnameSummer Undergraduate Research and Creative Achievements Forum (2007 : University of Missouri--Columbia)eng
dc.date2007eng
dc.date.issued2007eng
dc.descriptionAbstract only availableeng
dc.description.abstractThere is currently no cure for malignant melanoma and the best hope for a patient is early diagnosis and surgical excision. A promising approach to early cancer diagnosis is the use of radiolabeled peptides for tumor imaging. Dr. Quinn's lab has developed a cyclized peptide analog of alpha-Melanocyte stimulating hormone called ReCCMSH which binds to over expressed melanocortin-1 receptors on the tumor cells. A common radioimaging technique in nuclear medicine is positron emission tomography (PET). The radionuclide, fluorine-18, is widely used as a labeling agent for PET studies because of its 110 minute half life and low energy and is thus a good candidate for radiolabeling of our peptide. However, direct fluorination of the peptide is not possible. To radiolabel the peptide, a prosthetic group must be developed that can be attached to the peptide and act as a fluorine acceptor. This prosthetic group must not alter the biological properties of the peptide including receptor affinity, rapid body clearance, and absence of side reactions. The organic synthesis of this prosthetic group was the focus of my research. Previous attempts at radiolabeling of the conjugated peptide have been inefficient multi-step syntheses and thus impractical. For my research, a benzyl aldehyde was modified through a series of reactions to create carboxyl-3-cyano-4-N,N,N-trimethylanilinium triflate. This compound can be coupled to the end of the peptide and subsequently radiolabeled in one efficient step. The peptide was synthesized via solid phase peptide synthesis and cyclized via rhenium metal coordination. The actual radiolabeling of the conjugated peptide along with the in vivo biodistribution studies on mice will be pursued over the next academic year.eng
dc.identifier.urihttp://hdl.handle.net/10355/1292eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researcheng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forumeng
dc.source.urihttp://undergradresearch.missouri.edu/forums-conferences/abstracts/abstract-detail.php?abstractid=eng
dc.subjectcancer treatmenteng
dc.subjectpositron emission tomographyeng
dc.titleSynthesis of a prosthetic group for radiolabeling of Melanoma targeting peptide Re-CCMSH [abstract]eng
dc.typePresentationeng


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