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    Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy

    Youm, Ibrahima
    Yang, Xiao Y
    Murowchick, James B
    Youan, Bi-Botti C
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    [XML] 1556-276X-6-630.xml (88.75Kb)
    [PDF] 1556-276X-6-630.pdf (1.552Mb)
    [Word] 1556-276X-6-630-S1.DOC (69.5Kb)
    Date
    2011-12-14
    Format
    Journal Article
    Metadata
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    Abstract
    Abstract This study is designed to test the hypothesis that docetaxel [Doc] containing oily core nanocapsules [NCs] could be successfully prepared with a high percentage encapsulation efficiency [EE%] and high drug loading. The oily core NCs were generated according to the emulsion solvent diffusion method using neutral Labrafac CC and poly(d, l-lactide) [PLA] as oily core and shell, respectively. The engineered NCs were characterized for particle mean diameter, zeta potential, EE%, drug release kinetics, morphology, crystallinity, and cytotoxicity on the SUM 225 breast cancer cell line by dynamic light scattering, high performance liquid chromatography, electron microscopies, powder X-ray diffraction, and lactate dehydrogenase bioassay. Typically, the formation of Doc-loaded, oily core, polyester-based NCs was evidenced by spherical nanometric particles (115 to 582 nm) with a low polydispersity index (< 0.05), high EE% (65% to 93%), high drug loading (up to 68.3%), and a smooth surface. Powder X-ray diffraction analysis revealed that Doc was not present in a crystalline state because it was dissolved within the NCs' oily core and the PLA shell. The drug/polymer interaction has been indeed thermodynamically explained using the Flory-Huggins interaction parameters. Doc release kinetic data over 144 h fitted very well with the Higuchi model (R 2 > 0.93), indicating that drug release occurred mainly by controlled diffusion. At the highest drug concentration (5 μM), the Doc-loaded oily core NCs (as a reservoir nanosystem) enhanced the native drug cytotoxicity. These data suggest that the oily core NCs are promising templates for controlled delivery of poorly water soluble chemotherapeutic agents, such as Doc.
    URI
    http://dx.doi.org/10.1186/1556-276X-6-630
    http://hdl.handle.net/10355/13070
    Citation
    Nanoscale Research Letters. 2011 Dec 14;6(1):630
    Rights
    Youm et al.; licensee BioMed Central Ltd.
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    • BioMed Central Open Access Articles (UMKC)
    • Pharmaceutical Sciences Publications (UMKC)

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