Medications for weight loss in patients with Type 2 diabetes mellitus

Abstract

Fluoxetine (Prozac) and orlistat (Xenical) produce modest short-term weight loss, but their long-term benefits are unclear and their safety is uncertain. (Strength of Recommendation [SOR]: B, based on a meta-analysis of randomized controlled trials.) Topiramate (Topamax; immediate- and controlled-release formulations) can produce weight loss, but potential psychiatric and neurologic adverse effects limit its usefulness (SOR: B, based on randomized controlled trials.) Sibutramine (Meridia) produces weight loss but has been withdrawn from the U.S. market because of potential cardiovascular adverse effects.