How long does prenatal RhoGAM last?
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The total body load of anti-D immunoglobulin G (IgG) 12 weeks after a single 300-mcg dose of intramuscular anti-D immunoglobulin given at 28 weeks' gestational age (GA) is variable, ranging from undetectable to more than 25 mcg. Similarly variable total body loads result if 100 mcg of the immunoglobulin is given at both 28 and 34 weeks' GA. In many patients, therefore, the residual anti-D IgG will be insufficient to prevent Rh sensitization with the birth of an Rh D-positive infant. Routine administration of anti-D immunoglobulin within 72 hours of delivery of an Rh D-positive infant is therefore recommended. (SOR: B, based on consistent cohort studies.)
Evidence Based Practice 15(3): 07-08.