Browsing 2012 Dissertations (UMKC) by Thesis Department "Chemistry (UMKC)"
Now showing items 1-9 of 9
-
Conformational stability of some silanes and amines from temperature dependent Infrared spectra of rare as solutions, r₀ structural parameters, ab initio calculations, and vibrational assignments
(University of Missouri--Kansas City, 2012-06-12)The infrared (3600-40 cm-1) and Raman (3600-20 cm-1) spectra of numerous molecules containing silanes or amines have been recorded in the gas, liquid and solid phases. Additionally, variable temperature studies of the ... -
Development of drug conjugates in cancer therapy and evaluation of dual siRNA silencing effect on breast cancer growth and invasion
(University of Missouri--Kansas City, 2012)The objective of this dissertation is to present various approaches for treatment cancer, which is the leading cause of death worldwide. Compared to other disease, cancer has many unique biological characteristics that ... -
Evaluation of therapeutic effect of IKK epsilon SiRNA on breast cancer cells and development of a peptide-based SiRNA delivery system
(University of Missouri--Kansas City, 2012)The objective of this dissertation is to develop siRNA-based cancer therapeutics. In chapters 1 and 2, we introduced the mechanism, challenge and promise of RNAi-based therapy, as well as various siRNA delivery systems. ... -
Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
(University of Missouri--Kansas City, 2012)Recurrent brain tumors are one of the most lethal forms of solid tumors with poor prognosis. Molecularly targeted therapy, inhibiting the tyrosine kinase domain of epidermal growth factor receptor (EGFR), platelet derived ... -
Molecular assembly of polycyanoarenes with silver salts and synthesis of polycyclic aromatic hydrocarbonds
(University of Missouri--Kansas City, 2012)This dissertation encompasses the investigation of two distinct subjects. In the first part, which is in the area of molecular self-assembly, the complexation of organonitrile aryl compounds with three different types ... -
Molecular structure determination: solid-state NMR applications
(University of Missouri--Kansas City, 2012-12-14)Solid-state Nuclear Magnetic Resonance (ssNMR) has become one of the best techniques to determine molecular structure via inter/intra-molecular interactions. Unlike the well-known solution state NMR, solid-state NMR ... -
Ocular pharmacokinetics and efficacy of various amino acid and dipeptide prodrugs of ganciclovir
(University of Missouri--Kansas City, 2012-10-02)Herpes simplex virus infections (HSV) in the eye are one of the leading causes of blindness across the world. Current available treatment options to treat HSV infections are solutions of trifluorothymidine (TFT), idoxuridine ... -
Organoisocyanates: the conformational stability determination by infrared, raman and microwave spectroscopy and ab initio calculation
(University of Missouri-Kansas City, 2012)Conformational stability studies have been carried out for several quasilinear organoisocyanates and organoisothiocyanates. The infrared and Raman spectra in the gaseous, liquid and solid phases have been recorded as well ... -
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
(University of Missouri--Kansas City, 2012)Pentablock copolymers comprised of multi-polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL) and poly-lactide (PLA) were developed for fabrication of nanoparticles and thermosensitive hydrogel ...